A Gene-Centered C. elegans Protein-DNA Interaction Network
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منابع مشابه
Resource A Gene-Centered C. elegans Protein-DNA Interaction Network
Bart Deplancke, Arnab Mukhopadhyay, Wanyuan Ao, Ahmed M. Elewa, Christian A. Grove, Natalia J. Martinez, Reynaldo Sequerra, Lynn Doucette-Stamm, John S. Reece-Hoyes, Ian A. Hope, Heidi A. Tissenbaum, Susan E. Mango, and Albertha J.M. Walhout* Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA Huntsman C...
متن کاملA Gene-Centered C. elegans Protein-DNA Interaction Network
Transcription regulatory networks consist of physical and functional interactions between transcription factors (TFs) and their target genes. The systematic mapping of TF-target gene interactions has been pioneered in unicellular systems, using "TF-centered" methods (e.g., chromatin immunoprecipitation). However, metazoan systems are less amenable to such methods. Here, we used "gene-centered" ...
متن کاملA gene‐centered C. elegans protein–DNA interaction network provides a framework for functional predictions
Transcription factors (TFs) play a central role in controlling spatiotemporal gene expression and the response to environmental cues. A comprehensive understanding of gene regulation requires integrating physical protein-DNA interactions (PDIs) with TF regulatory activity, expression patterns, and phenotypic data. Although great progress has been made in mapping PDIs using chromatin immunopreci...
متن کاملA gene-centered C. elegans protein-DNA interaction network provides a backbone for functional predictions
Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from two of the three referees who agreed to evaluate your study. Reviewer #2 has informed us that s/he is not going to be able to provide comments in a timely manner, so in the interest of time, I prefer to make a decision based on the two available reports. As you will see below, the reviewers acknow...
متن کاملTranscription factor modularity in a gene-centered C. elegans core neuronal protein-DNA interaction network.
Transcription regulatory networks play a pivotal role in the development, function, and pathology of metazoan organisms. Such networks are comprised of protein-DNA interactions between transcription factors (TFs) and their target genes. An important question pertains to how the architecture of such networks relates to network functionality. Here, we show that a Caenorhabditis elegans core neuro...
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ژورنال
عنوان ژورنال: Cell
سال: 2006
ISSN: 0092-8674
DOI: 10.1016/j.cell.2006.04.038